Newborn Skeletal Deformalities with Renal Agenesis: A Complication of Severe Oligohydramnious and Hypothyroidism

Abstract

Hypothyroidism can be pre-existent or may begin during pregnancy period. Hypothyroidism is difficult to be diagnosed during pregnancy as the signs can belong to pregnancy itself. Changes in thyroid function have a major negative impact on both mother and fetus. The occurrence of hypothyroidism during pregnancy is projected to be 0.3−0.5% for overt hypothyroidism and 2−3% for subclinical hypothyroidism. Autoimmune thyroiditis is the shared cause of hypothyroidism during pregnancy. Maternal hypothyroidism during pregnancy has been largely associated with a wide range of adverse outcomes, most importantly with miscarriage, preterm delivery and reduced cognitive function in offspring including fetal loss, pre-eclampsia, polyhydramnios/oligohydramnious, intrauterine growth retardation, caesarean section, vacuum delivery, post partum hemorrhage and small or large for gestational age. Here, we report a hypothyroidism mother with prompt diagnosis of severe oligohydramnious (AFI: 2.5 cm) that was complicated with late preterm (36 plus weeks) newborn baby with skeletal deformity and renal agenesis. Here, we report a Hypothyroidism mother with prompt diagnosis of severe Oligohydraminous (AFI-2.5cm) that was complicated with late preterm (36+weeks) newborn baby with skeletal deformity and renal agenesis.