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Effect of Information Booklet on Prevention of Hand-foot Syndrome

Lanah Saniiru Ng, Andrews R. Gaddam, Gogia Ajay

Abstract


Hand-foot syndrome (HFS) an important side effect of fluorouracil (5 FU) and capecitabine is a
debilitating condition which adversely affect performance status in patients experiencing the severity
of this symptom thus impairing the quality of life. So early recognition and reporting of symptoms is
important to prevent progression to severe grade. Previous study suggested that written material can
be provided to patients for early identification and management of symptoms. Aims of the study are to
assess the efficacy of written material (information booklet) on improving knowledge and prevention
of HFS in cancer patients receiving 5 FU and Capecitabine. This prospective randomized control
trial with 81 patients, n=40 experimental and n=41 control group was conducted at medical oncology
day-care unit in tertiary hospital, Delhi. Pre-test was administered with knowledge questionnaire and
HFS checklist. Experimental group received information booklet along with standard routine care.
Control group received standard routine care alone. Post-test was taken on 22nd day. STATA 12.1
was used for data analysis. Frequencies, means paired t-test, chi square, and one-way ANOVA test
were used. Results show that knowledge score in experimental group was higher compared to control
group at (p<0.001) in post-test. Hand-foot syndrome grades were comparable between the groups at
baseline (p=0.1) as well as in post-test (p=0.76). Knowledge was significantly associated with HFS
grades. Patients with higher HFS grade had higher knowledge as compared to lower grade at
(p=0.003). Information booklet significantly increase the knowledge regarding HFS in cancer
patients. However, the efficacy of information booklet on prevention of hand-foot syndrome could not
be established.


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References


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