Effect of Information Booklet on Prevention of Hand-foot Syndrome
Abstract
Hand-foot syndrome (HFS) an important side effect of fluorouracil (5 FU) and capecitabine is a
debilitating condition which adversely affect performance status in patients experiencing the severity
of this symptom thus impairing the quality of life. So early recognition and reporting of symptoms is
important to prevent progression to severe grade. Previous study suggested that written material can
be provided to patients for early identification and management of symptoms. Aims of the study are to
assess the efficacy of written material (information booklet) on improving knowledge and prevention
of HFS in cancer patients receiving 5 FU and Capecitabine. This prospective randomized control
trial with 81 patients, n=40 experimental and n=41 control group was conducted at medical oncology
day-care unit in tertiary hospital, Delhi. Pre-test was administered with knowledge questionnaire and
HFS checklist. Experimental group received information booklet along with standard routine care.
Control group received standard routine care alone. Post-test was taken on 22nd day. STATA 12.1
was used for data analysis. Frequencies, means paired t-test, chi square, and one-way ANOVA test
were used. Results show that knowledge score in experimental group was higher compared to control
group at (p<0.001) in post-test. Hand-foot syndrome grades were comparable between the groups at
baseline (p=0.1) as well as in post-test (p=0.76). Knowledge was significantly associated with HFS
grades. Patients with higher HFS grade had higher knowledge as compared to lower grade at
(p=0.003). Information booklet significantly increase the knowledge regarding HFS in cancer
patients. However, the efficacy of information booklet on prevention of hand-foot syndrome could not
be established.
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Chiara S, Nobile MT, Barzacchi C, Sanguineti O, Vincenti M, Somma CD, et al. Hand-foot
syndrome induced by high-dose, short-term, continuous 5-fluorouracil infusion. Eur J Cancer.
; 33: 967–969.
Saif M W, Elfiky AA. Identifying and treating fluoropyrimidine-associated Hand and foot
syndrome in white and non-white patients. J support Oncol. 2007; 5: 337–343.
Twelves C, Wong A, Nowacki MP, Abt M, Burris H, Carrato A, et al. Capecitabine as adjuvant
treatment for stage III colon cancer. N Engl J Med 2005; 352: 2696–70.
Son H-S, Lee WY, Lee W-S, Yun SH, Chun H-K. Compliance and effective management of the
hand-foot syndrome in colon cancer patients receiving capecitabine as adjuvant chemotherapy.
Yonsei Med J. 2009 Dec 31; 50: 796–802.
Abushullaih S, Saad ED, Munsell M, Hoff PM. Incidence and severity of hand-foot syndrome in
colorectal cancer patients treated with capecitabine: a single-institution experience. Cancer Invest.
Jan 1; 20: 3–10.
Gordon KB, Tajuddin A, Guitart J, Kuzel TM, Eramo LR, Vonroenn J. Hand-foot syndrome
associated with liposome-encapsulated doxorubicin therapy. Cancer. 1995; 75: 2169–2173.
Nagore E, Insa A, Sanmartin O. Antineoplastic therapy induced palmar plantar erythrodysesthesia
syndrome. Incidence, recognition and management. Am J Clin Dermatol. 2000 July; 1: 225–34.
Janusch M, Fischer M, Marsch W. Ch, Holzhausen HJ, Kege T, Helmbol P. The hand-foot
syndrome – a frequent secondary manifestation in antineoplastic chemotherapy: Eur J Dermatol.
; 16: 494–9.
Meta-Analysis Group in Cancer. Toxicity of fluorouracil in patients with advanced colorectal
cancer: effect of administration schedule and prognostic factors. J Clin Oncol 1998; 16: 3537–
Clark AS, Vahdat LT. Chemotherapy-induced palmar-plantar erythrodysesthesia syndrome:
Etiology and emerging therapies. Support Cancer Ther. 2004; 1: 213–218.
Feliu, Safont MJ, Salud A, Losa F, García-GirónC, Bosch C, et al. Capecitabine and bevacizumab
as first-line treatment in elderly patients with metastatic colorectal cancer. Br Cancer. 2010; 102:
–1473.
Son H-S, Lee WY, Lee W-S, Yun SH, Chun H-K. Compliance and effective management of the
hand-foot syndrome in colon cancer patients receiving capecitabine as adjuvant chemotherapy.
Yonsei Med J. 2009 Dec 31; 50: 796–802.
Bano N, Najam R, Mateen A. Comparative assessment of skin and subcutaneous toxicity in
patients of advanced colorectal carcinoma treated with different schedules of FOLFOX. Asian
Pac J Cancer Prev. 2013; 14: 1781–1786.
Gerbrecht B-MR. Current Canadian experience with capecitabine. partnering with patients to
optimize therapy. Cancer Nurs. 2003 Apr; 26: 161–167.
Degen A, Alter M, Schenck F, Satzger I, Völker B, Kapp A, et al. The hand-foot-syndrome
associated with medical tumor therapy–classification and management. JDDG. 2010; 8: 652–66.
Von Moos R, Thuerlimann BJK, Aapro M, Rayson D, Harrold K, Sehouli J, et al. Pegylated
liposomal doxorubicin-associated hand-foot syndrome: Recommendations of an international
panel of experts. Eur J Cancer. 2008 Apr; 44: 781–90.
Suto T, Ishiyama K, Mori N, Inoue K, Chiba M, Igawa A, et al. Adverse events in patients treated
with capecitabine as adjuvant chemotherapy after surgery for colorectal cancer- countermeasures
against hand foot syndrome. GanTo Kagaku Ryoho. 2010 Sep; 37: 1729–33.
Lassere Y, Hoff P. Management of hand-foot syndrome in patients treated with capecitabine
(Xeloda). Eur J Oncol Nurs. 2004; 8 Suppl 1: S31–40.
Waller A, Forshaw K Bryant J, Mair S. Interventions for preparing patients for chemotherapy and
radiotherapy: a systematic review. Supportive Care Cancer. 2014 August; 22: 2297–2308.
Anderson R, Jatoi A, Robert C, Wood LS, Keating KN, Lacouture ME. Search for evidence-based
approaches for the prevention and palliation of Hand –foot skin reaction (HFSR) caused by the
mulikinase inhibitors (MKIs). The Oncologist. 2009; 14: 291–302.
Zhao Y, Ding Y, Lu Y, Zhang J, Gu J, Li M. Incidence and self-management of hand-foot
syndrome in patients with colorectal cancer. Clin J Oncol Nurs. 2013 August1; 17: 434–437.
Meade CD, McKinney WP, Bamas GP. Educating patients with limited literacy skills: the
effectiveness of printed and videotaped materials about colon cancer. Am J Public Health.1994;
: 1.
Andrews GR. A study to identify the self-care deficit amongst the cancer chemotherapy patients
with a view to develop and test the effectiveness of self-instructional material in the management
of cancer chemotherapy patients in selected hospital. Nurs J India.1997; 23: 179–181.
Christine J. McPherson, Irene J. Higginson, Hearn J. Effective methods of giving information in
cancer: a systematic literature review of randomized controlled trials. J Public Health Med. 2001;
: 227–234.
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